Last month's question:
Of the following substances which one is responsible for stimulating appetite?
Answer: Neuropeptide Y
Insulin reduces appetite centrally by reducing neuropeptide Y concentration.
Neuropeptide Y is produced in the hypothalamus, adrenal and sympathetic nerves. It does not cross the blood-brain barrier. Given centrally to rats it induces eating.
Leptin is elevated in obese people. Low levels are found in starvation, and low levels stimulate eating. High levels probably have no effect.
Cholecystokinin acts peripherally via the vagus to reduce appetite. Centrally it produces a feeling of satiety. Serotonin agonists are used as anorexigens.
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