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2

Moderate alcohol benefits: only for 15% of population

from MNTcvs - 15 Nov 14

A new study confirms that moderate alcohol consumption can protect against coronary heart disease, but only for the 15% of the population that have a particular genotype.



2

Researchers discover type of toxic flame retardant in Americans for first time

from MNToncology - 15 Nov 14

By finding a way to test urine for phosphate biomarkers, researchers have identified a previously undiscovered toxic flame retardant - TCEP - in Americans.



2

Life Expectancy in Patients With Chronic HCV Infection and Cirrhosis Compared With a General Population

from JAMA - 12 Nov 14

Almost 3 million people in the United States are chronically infected with the hepatitis C virus (HCV). The life expectancy of patients with chronic HCV infection is reduced compared with the general population, largely attributable to the development of cirrhosis, liver failure, and hepatocellular carcinoma.



2

Cardiac Assessment Before Stem Cell Transplantation for Systemic Sclerosis

from JAMA - 05 Nov 14

To the Editor The key to safe hematopoietic stem cell transplantation in patients with systemic sclerosis is a careful pretransplant cardiac assessment and subsequent recognition and management of cardiac complications. In the Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial by Dr van Laar and colleagues, the main exclusion criteria for cardiac reasons were left ventricular ejection fraction less than 45% and pulmonary arterial hypertension, defined as a mean pulmonar



2

Artificial Sweeteners May Promote Metabolic Disorders

from JAMA - 05 Nov 14

Mice fed artificial sweeteners for 11 weeks develop glucose intolerance, a precursor to type 2 diabetes, due to alterations in the composition of their gut microbes, researchers from Israel’s Weizmann Institute of Science have reported (Suez J et al. Nature. doi:10.1038/nature13793 [published online September 17, 2014]). Treating the animals with antibiotics abrogated these metabolic effects.



2

Incorrect Labels for Numbers at Risk

from JAMA - 05 Nov 14

In the Original Investigation entitled “Association of Atrial Tissue Fibrosis Identified by Delayed Enhancement MRI and Atrial Fibrillation Catheter Ablation: The DECAAF Study” published in the February 5, 2014, issue of JAMA (2014;311[5]:498-506. doi:10.1001/jama.2014.3), the rows of numbers at risk were incorrectly labeled in Figure 4. The curves in Figure 4 are labeled correctly but underneath the figure, the rows of numbers at risk are incorrectly labeled and should correspond to the order i



2

Trial results reveal first targeted treatment to boost survival for oesophageal cancer

from Cancer Research News - 05 Nov 14

Press release Patients with a specific type of oesophageal cancer survived longer when they were given the latest lung cancer drug, according to trial results being presented at the National Cancer Research Institute (NCRI) Cancer Conference today (Wednesday). Up to one in six patients with oesophageal cancer were found to have EGFR duplication in their tumour cells and taking the drug gefitinib, which targets this fault, boosted their survival by up to six months, and sometimes beyond. "It’s



2

Anesthesia Technique and Outcomes After Hip Fracture Surgery—Reply

from JAMA - 05 Nov 14

In Reply Our study evaluated the association between anesthesia technique and outcome among patients with hip fracture, observing an indeterminate effect of anesthesia technique on 30-day mortality and a shorter inpatient length of stay with regional anesthesia.



2

Ethical Considerations Surrounding Lethal Injection—Reply

from JAMA - 05 Nov 14

In Reply The report by the Committee of The Constitution Project correctly states that “Doctors and other medical professionals should not be compelled to violate medical ethics,” and former Governor White adds that if there is indeed consensus that no medical personnel could ever ethically participate in executions, then the report should be read as completely prohibiting the use of lethal injection as a method of execution in the United States. The message of our Viewpoint was that there is so



2

Anesthesia Technique and Outcomes After Hip Fracture Surgery

from JAMA - 05 Nov 14

To the Editor Dr Neuman and colleagues concluded that the use of regional anesthesia compared with general anesthesia after hip fracture surgery was not associated with lower 30-day mortality. This finding suggests that previous large observational studies have overestimated the mortality benefit of regional anesthesia. The authors attempted to overcome the potential selection bias of previous studies by using multivariable matching and instrumental variable analysis.



2

Sepsis-related deaths in Brazil: an analysis of the national mortality registry from 2002 to 2010

from Critical Care Forum - 05 Nov 14

IntroductionLimited population-based epidemiologic information about sepsis? demography, including its mortality and temporal changes is available from developing countries. We investigated the epidemiology of sepsis deaths in Brazil using secondary data from the Brazilian Mortality Information System. Methods: Retrospective descriptive analysis of Brazilian multiple-cause-of-death data between 2002 and 2010, with sepsis-associated International Classification of Diseases, 10th Revision (ICD-10)



2

Gene 'switches' could predict when breast cancers will spread to the brain

from Cancer Research News - 05 Nov 14

Press release Scientists have found a pattern of genetic ‘switches’ – chemical marks that turn genes on or off - that are linked to breast cancer’s spread to the brain, according to research* presented at the National Cancer Research Institute Cancer Conference in Liverpool today (Wednesday). "Tackling the problem of brain metastases is one of the greatest challenges facing breast cancer researchers" - Dr Abeer Shaaban The researchers, based at the University of Wolverhampton, studied 24 breas



2

Cardiac Assessment Before Stem Cell Transplantation for Systemic Sclerosis—Reply

from JAMA - 05 Nov 14

In Reply Dr Burt and colleagues emphasize the importance of extensive cardiopulmonary screening before undertaking autologous hematopoietic stem cell transplantation in patients with severe systemic sclerosis. When the ASTIS trial was launched in 2001, phase 1/2 data indicated that patients with systemic sclerosis and a mean pulmonary arterial pressure greater than 50 mm Hg measured by right heart catheterization had an unacceptable risk of treatment-related mortality and were therefore excluded



2

Ethical Considerations Surrounding Lethal Injection

from JAMA - 05 Nov 14

To the Editor Perhaps no part of the criminal justice system is more fraught with moral, ethical, and legal dilemmas than the execution process. The paramount concern of the Death Penalty Committee of The Constitution Project was to ensure that the system is as fair and transparent as possible and comports with the numerous protections found in the US Constitution. As Dr Truog and colleagues pointed out, the Committee of The Constitution Project found that the justice system fails to do this in



2

Rate of Suicide Increases in Middle Age Primary Care Key to Suicide Prevention

from JAMA - 05 Nov 14

The recent suicide death of comedian Robin Williams drew attention to a worrisome public health trend: a rising rate of suicide among middle-aged individuals.



2

The Lady in Mauve Lyonel Feininger

from JAMA - 05 Nov 14

City living can be treacherous. A misplaced step on an uneven sidewalk can sprain an ankle, bags not held closely are ripe for would-be snatchers, tumultuous winds can turn an umbrella, and a distracted driver can terrorize pedestrians. Day-to-day living can at the very least be inelegant, and at the very worst traumatic. The city can some days get the best of anyone. Yet many artists of the early 20th century looked past these inconveniences to see opportunities for artistic expression. The mo



2

Popular Beliefs and Scientific Facts

from JAMA - 05 Nov 14

Popular beliefs on scientific subjects apparently run in waves. Many of our readers remember the interest in hypnotism which followed the publication of “Trilby.” Svengali with his “hypnotic eye” at once became a real and possible personage in the public imagination. The newspapers were full of stories of girls and women who had suddenly been fixed and paralyzed by the hypnotic gaze of some mysterious stranger with piercing black eyes and who had been compelled by his will to fantastic acts whic



2

JAMA

from JAMA - 05 Nov 14



2

Recent Suicides Highlight Need to Address Depression in Medical Students and Residents

from JAMA - 05 Nov 14

The accomplished young man graduated medical school in May and, as a resident, quickly impressed his coworkers.



2

Banked Blood Cells Lose Functionality Over Time

from JAMA - 05 Nov 14

Stored red blood cells retain their shape, mass, and hemoglobin content over time, but the membranes eventually become stiffer and less elastic, making them less capable of transporting oxygen through capillaries (Bhaduri B et al. Sci Rep. 2014;4:6211).



2

Early Signs of Pancreatic Cancer

from JAMA - 05 Nov 14

Scientists who analyzed blood samples collected over time from 1500 participants in large prospective studies reported that elevated levels of branched-chain amino acids were linked with increased odds of developing pancreatic cancer (Mayers JR et al. Nat Med. doi:10.1038/nm.3686 [published online September 28, 2014]). The strongest association was observed among patients with samples collected 2 to 5 years before cancer diagnosis. The research team included investigators at Dana-Farber Cancer I



2

Hypertension May Be an Autoimmune Disease

from JAMA - 05 Nov 14

New research suggests that oxidation and inflammation may cause alterations in self-proteins that activate an immune response, leading to blood pressure elevation (Kirabo A et al. J Clin Invest. doi:10.1172/JCI74084 [published online September 17, 2014]).



2

Racial Disparity in Breastfeeding

from JAMA - 05 Nov 14

Hospitals and birth centers in US regions with a higher-than-average percentage of black residents are less likely to have breastfeeding support for new mothers than facilities in areas where the black population is lower than the national average, according to recent data.




2

Treating Adolescent Mental Health Problems Without Medication

from JAMA - 05 Nov 14

Recent research shows that most US adolescents treated for serious emotional or behavioral difficulties don’t receive prescription medication.


 

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