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Sensitivity of Immunofluorescence Studies vs Enzyme-Linked Immunosorbent Assay for Diagnosis of Bullous Pemphigoid [Correspondence]

from ArchDerm - 19 Dec 11

Discovery Of Protective Gene In Fat Cells May Lead To A Therapeutic For Type 2 Diabetes

from MNTdiabetes - 02 Apr 12

In a finding that may challenge popular notions of body fat and health, researchers at Beth Israel Deaconess Medical Center (BIDMC) have shown how fat cells can protect the body against diabetes. The results may lead to a new therapeutic strategy for preventing and treating type 2 diabetes and obesity-related metabolic diseases, the authors say...

Relationship Between the Depth of Facial Wrinkles and the Density of the Retinacula Cutis [Study]

from ArchDerm - 16 Jan 12

Objective  To identify whether there is a relationship between the depth of facial wrinkles and the density of the retinacula cutis in the subcutaneous tissue of the skin. Design  Wrinkle depth was assessed with image analysis on the forehead and the lateral canthus of human cadavers. The density of the retinacula cutis was measured in Azan-Mallory–stained skin sections obtained around the wrinkles. Setting  Gross Anatomy Section, Kagoshima University Graduate School of Med

Projected Clinical Outcomes of Glaucoma Screening in African American Individuals [Socioeconomics and Health Services]

from ArchOpht - 12 Mar 12

Objectives  To project the clinical impact of routine glaucoma screening on visual outcomes in middle-aged African American individuals and help guide glaucoma screening policy. Methods  Using data from the Eye Diseases Prevalence Research Group and Baltimore Eye Study, we developed a microsimulation model to project visual outcomes in African American individuals screened for glaucoma under a national screening policy using frequency-doubling technology. We projected the impact of un

Positive Feedback And Tumorigenesis, A Vicious Circle That Promotes Cell Proliferation

from MNToncology - 23 Dec 11

Cancer cells are essentially immortal. The acquisition of an unlimited capacity to divide the process of immortalization is a central event in the genesis of tumors. Normally, cells are subject to stringent mechanisms which control their proliferation. Together these ensure that pre-malignant cells are induced to enter a senescent, non-dividing state or to undergo apoptosis, i.e. commit suicide...

Likely New Trigger For Epidemic Of Metabolic Syndrome Discovered

from MNTdiabetes - 24 Feb 12

UC Davis scientists have uncovered a key suspect in the destructive inflammation that underlies heart disease and diabetes. The new research shows elevated levels of a receptor present on leucocytes of the innate immune response in people at risk for these chronic diseases...

Revising The 'Textbook' On Liver Metabolism Offers New Targets For Diabetes Drugs

from MNTdiabetes - 23 Feb 12

A team led by researchers from the Institute for Diabetes, Obesity and Metabolism (IDOM) at the Perelman School of Medicine, University of Pennsylvania, has overturned a "textbook" view of what the body does after a meal. The study appears online this week in Nature Medicine, in advance of print publication...

Actinic Keratosis Treatment Newly On Prescription

from MNTderm - 18 Mar 12

A new topical gel now available by prescription significantly decreases the amount of time needed to treat actinic keratosis, a skin condition that is a common precursor to skin cancer, according to a multi-center trial led by researchers at Mount Sinai School of Medicine...

Detecting Down Syndrome Risk - Noninvasive Method Efficient and Accurate

from MNTpaeds - 24 Feb 12

Two studies published online, ahead of the April issue of the American Journal of Obstetrics & Gynecology (AJOG), show that the risk of a fetus having chromosomal abnormalities that cause Down syndrome, and a genetic disorder known as Edwards syndrome, can now be almost precisely be identified by using a noninvasive test on maternal blood that involves a novel biochemical assay...

Playing Video Games May Benefit Kids With Cerebral Palsy

from MNTpaeds - 10 May 12

According to a study published online in the Archives of Physical Medicine and Rehabilitation, children with cerebral palsy (CP) may benefit from playing active video games (AVG), such as Nintendo's Wii...

Diagnosing diabetes on admission hyperglycaemia.

from Diabetes abs. - 28 Jan 12

Diagnosing diabetes on admission hyperglycaemia. Heart. 2012 Jan;98(1):3-4 Authors: Qureshi AC, Asherson AP, Grossman AB PMID: 21954227 [PubMed - indexed for MEDLINE]

Cardiovascular Disease Prevention Guidelines - Benchmarking Study Triggers Rethink

from MNTcvs - 24 Feb 12

The 2012 Joint European CVD Prevention Guidelines , that will be published at the EuroPRevent 2012 later this year, will be more concise, compact and supported by fewer references, according to Professor Joep Perk, Chairperson of the Task Force of the fifth edition, who states that the aim is to provide guidelines that contain recommendations, which can be readily applied and t...

Concussion A Serious Hazard For Teenagers

from MNTpaeds - 01 Mar 12

A new study has demonstrated that adolescents are more vulnerable to sport-related concussion, compared with adults or children...

Making Personalized Cancer Therapies More Cost Effective

from MNToncology - 13 Mar 12

As scientists continue making breakthroughs in personalized cancer treatment, delivering those therapies in the most cost effective manner has become increasingly important. Now researchers at the University of Colorado School of Medicine have identified new ways of doing just that, allowing more patients to benefit from this revolution in cancer care...

Thyroid-Associated Periorbitopathy: Of Mountains, Measurements, and Levels of Evidence [Editorial]

from ArchOpht - 12 Mar 12

Human Papilloma Virus Vaccine Should Be Given To Boys, According To AAP

from MNTpaeds - 28 Feb 12

A recent study, published in the journal Pediatrics , explains that males should be getting the vaccine for human papilloma viruses (HPV), not only females. It is recommended by professionals that young people should start receiving the vaccine around age 11...

Discovery Could Reduce Chemo's Side Effects

from MNToncology - 13 Mar 12

A team of researchers at Duke University has determined the structure of a key molecule that can carry chemotherapy and anti-viral drugs into cells, which could help to create more effective drugs with fewer effects to healthy tissue...

Research Suggests Omega-3 Fatty Acids Could Prevent And Treat Nerve Damage

from MNTneuro - 12 Jan 12

Research from Queen Mary, University of London suggests that omega-3 fatty acids, which are found in fish oil, have the potential to protect nerves from injury and help them to regenerate. When nerves are damaged because of an accident or injury, patients experience pain, weakness and muscle paralysis which can leave them disabled, and recovery rates are poor...

Endogenous Cushing's Syndrome - FDA Approves Korlym (Mifepristone)

from MNTdiabetes - 22 Feb 12

The U.S. Food and Drug Administration has approved Korlym (mifepristone) to control hyperglycemia (high blood sugar levels) in adults with endogenous Cushing's syndrome, who have type 2 diabetes or glucose intolerance, who remained unresponsive to previous surgery or are not eligible candidates for surgery. Pregnant women should never take Korlym (contraindicated)...

Medical emergencies on board commercial airlines: is documentation as expected?

from Critical Care Forum - 07 Mar 12

IntroductionThe purpose of this study was to perform a descriptive, content-based analysis on the different forms of documentation for in-flight medical emergencies that are currently provided in the emergency medical kits on board commercial airlines. Methods: Passenger airlines in the World Airline Directory were contacted between March and May 2011. For each participating airline, sample in-flight medical emergency documentation forms were obtained. All items in the sample documentation forms

Study Suggests Underage Drinking Laws Reduce Future Criminal Behavior

from MNTpaeds - 27 Feb 12

Do strict underage drinking laws really have a positive impact on society? A recent study finds that strictly enforcing possession of alcohol under the legal age or PULA (also known as PAULA) laws on teenagers reduces the likelihood that they will engage in alcohol-related crime as adults...

A Firmer Understanding Of Muscle Fibrosis In Duchenne Muscular Dystrophy

from MNTbone - 03 Jan 12

Researchers describe how increased production of a microRNA promotes progressive muscle deterioration in a mouse model of Duchenne muscular dystrophy (DMD), according to a study published online on January 2 in the Journal of Cell Biology*. As DMD patients age, their damaged muscle cells are gradually replaced by collagen-rich, fibrous tissue...

Intra-arrest hypothermia during cardiac arrest: a systematic review

from Critical Care Forum - 07 Mar 12

IntroductionTherapeutic hypothermia is largely used to protect the brain following return of spontaneous circulation (ROSC) after cardiac arrest (CA), but it is unclear whether we should start therapeutic hypothermia earlier, i.e., before ROSC. Methods: We performed a systematic search of PubMed, EMBASE, CINAHL, the Cochrane Library and Ovid/Medline databases using "arrest" OR "cardiac arrest" OR "heart arrest" AND "hypothermia" OR "therapeutic hypothermia" OR "cooling" as keywords. Only studies

Effects of Statins on Energy and Fatigue With Exertion: Results From a Randomized Controlled Trial

from ArchInte - 13 Aug 12

No drug is without adverse effect potential, and fatigue and exertional intolerance are adverse effects reported by patients receiving statins. Little direct information is available regarding the typical or average impact of statins on energy or exertional fatigue.

Early Birth Tied To Health Risks In Early Years

from MNTpaeds - 02 Mar 12

A new UK study finds that babies born early, even by just a few weeks, tend to have higher risks of poor health in their early years, compared to those born full term. The study challenges the widely held view that the long term health outcomes for moderate and late preterm babies, even up to 37 or 38 weeks of gestation, are similar to those carried to full term...