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Patient With Gorlin Syndrome and Metastatic Basal Cell Carcinoma Refractory to Smoothened Inhibitors

from ArchDerm - 01 Aug 14

ImportanceBasal cell carcinomas (BCCs) in patients with Gorlin syndrome have been reported to be extremely sensitive to Smoothened (SMO) inhibitors, a novel targeted therapy against the Hedgehog pathway, because of characteristic mutations in these patients. A few cases of disease refractory to oral therapy with SMO inhibitors have been reported in patients with Gorlin syndrome and nonmetastatic BCCs, but refractory disease in distantly metastatic tumors has not been documented in this high-risk



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D-Dimer Levels as a Marker of Cutaneous Disease Activity Case Reports of Cutaneous Polyarteritis Nodosa and Atypical Recurrent Urticaria

from ArchDerm - 01 Aug 14

ImportanceBiochemical markers of disease allow clinicians to monitor disease severity, progression, and response to treatment. C-reactive protein and erythrocyte sedimentation rate are commonly used biochemical markers of inflammatory disease. We present 2 cases that indicate that D-dimer levels may be useful as a potential biochemical marker of disease activity in certain cutaneous inflammatory conditions.ObservationsWe report 2 cases in which clinical disease activity correlates with D-dimer l



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Atrophic Skin Patches With Abnormal Elastic Fibers as a Presenting Sign of the MASS Phenotype Associated With Mutation in the Fibrillin 1 Gene

from ArchDerm - 01 Aug 14

ImportanceMarfan syndrome (MFS) is a dominantly inherited disorder of connective tissue caused by mutations in the fibrillin 1 gene (FBN1). The most common skin finding in MFS is striae distensae. Particular individuals referred for suspected MFS who do not completely fulfill the MFS diagnostic criteria are classified as having a MASS phenotype. The acronym represents the following manifestations: a prolapsed mitral valve, myopia, aortic root enlargement, and skeletal and skin manifestations. Mu







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Sun Protection Behaviors Among Puerto Rican Adults

from ArchDerm - 01 Aug 14

The incidence of skin cancer has been increasing among US Hispanics for several decades. Hispanic individuals residing in the continental United States do not sufficiently engage in routine sun protection behaviors. Hispanics are an important population to target for skin cancer prevention research and public health initiatives. However, there is a dearth of such efforts focusing on Hispanic populations outside the continental United States. From 1974 to 2005, the skin cancer incidence in Puerto



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Risk for Nevus Transformation and Melanoma Proliferation and Invasion During Natalizumab Treatment Four Years of Dermoscopic Follow-up With Immunohistological Studies and Proliferation and Invasion As

from ArchDerm - 01 Aug 14

Natalizumab is a monoclonal antibody targeting a4 integrin used to treat multiple sclerosis (MS). Seven cases of melanoma during natalizumab treatment have been reported since 2006. The objective of this study was to assess the effect of natalizumab on nevi transformation and tumor cell proliferation, invasion, and migration in preclinical models of melanoma.



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Methotrexate-Induced Liver Toxicity Replacing the Liver Biopsy

from ArchDerm - 01 Aug 14

Methotrexate-induced hepatotoxicity in patients with psoriasis occurs rarely and unpredictably. Although liver monitoring must occur, dermatologists currently lack a reliable test. Unfortunately, many of the current recommendations for the monitoring of patients with psoriasis are poorly substantiated by rigorous data. For example, cumulative methotrexate dosage appears to be irrelevant. In addition, the liver biopsy, considered the criterion standard, suffers from sampling error, intraobserver



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Cholesterol Embolization Syndrome With an Atypical Proximal Presentation Simulating Calciphylaxis

from ArchDerm - 01 Aug 14

Cholesterol embolization syndrome (CES) is associated with endovascular procedures or anticoagulation, which disrupt atheromatous plaques within large arteries releasing cholesterol crystals. These crystals lodge in the vasculature of various organs, most commonly the skin. Cutaneous involvement classically presents in the distal lower extremities as livedo reticularis (49%), gangrene (35%), cyanosis (28%), ulceration (17%), nodules (10%), purpura (9%), and splinter hemorrhages. We report a case



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Acinetobacter baumannii Emerging as a Multidrug-Resistant Skin and Soft-Tissue Pathogen Parallels to Methicillin-Resistant Staphylococcus aureus

from ArchDerm - 01 Aug 14

Over the last 30 years, the gram-negative coccobacillus Acinetobacter baumannii has risen to microbiologic notoriety for its ability to successfully evade nearly all available antibiotics. It is now a well-established source of nosocomial bacteremia and pneumonia, known to cause hospital outbreaks, particularly in the intensive care unit. Less often it represents a source of nosocomial skin and soft-tissue infection (SSTI) in the setting of war wounds, surgical sites, and burns.



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Primary Cutaneous Follicle Center Lymphoma With Follicular Mucinosis

from ArchDerm - 01 Aug 14

Follicular mucinosis (FM) is defined as the accumulation of a mucinous material within the hair follicle. Since its first description by Pinkus in 1957 in the setting of alopecia mucinosa, 2 main forms have been classically recognized: a benign idiopathic form, primary follicular mucinosis (PFM), which usually appears in young adults and regresses spontaneously; and a secondary form, lymphoma-associated follicular mucinosis (LAFM), which mostly occurs in elderly patients. Most cases of LAFM are



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Periorbital Subcutaneous Emphysema Mistaken for Unilateral Angioedema During Dental Crown Preparation

from ArchDerm - 01 Aug 14

Subcutaneous emphysema, defined as the abnormal introduction of air into subcutaneous tissues, is a rare complication of dental treatment. More common causes of this entity include trauma, head and neck surgery, and general anesthesia. We present a case of periorbital subcutaneous emphysema that clinically appeared as unilateral angioedema during a dental treatment.



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Recurrent Abscesses of the Neck Scrofuloderma

from ArchDerm - 01 Aug 14

Tuberculosis of the skin has become a rare disease in industrialized countries. Polymerase chain reaction (PCR) is a powerful diagnostic tool for mycobacterial infections of the skin, but it can fail, as demonstrated in this case.



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Dermatitis and Dangerous Diets A Case of Kwashiorkor

from ArchDerm - 01 Aug 14

Although uncommon, kwashiorkor continues to occur in developed nations. A recent case highlights the fact that such occurrences are typically the result of well-meaning dietary restriction in the setting of nutritional ignorance. Telltale skin and hair changes should prompt a thorough dietary history and appropriate dietary intervention.



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Dermatitis Herpetiformis

from ArchDerm - 01 Aug 14

The Journal of Cutaneous DiseasesAugust 1914DERMATITIS HERPETIFORMIS. Presented by Dr. Mount* * *Dr. Parounagian said he had a similar case which he had presented at this Society which cleared up entirely under absolute milk diet and remained free from lesions, but as soon as he resumed regular diet his lesions reappeared.* * *Dr. Geyser said that as he had not seen the case he would only call attention to a statement by Dr. Parounagian, concerning a case of his that did well the moment



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Demystifying Merkel

from ArchDerm - 01 Aug 14

The Merkel cell represents 1 of the 4 types of cells that make up the epidermis. But how did it get its name? Friedrich Sigmund Merkel was born in Nuremberg, Germany, in 1845. He earned his medical degree from the University of Erlangen at 24 years of age. After medical school, he accepted a position of prosector at the University Medical Center of Göttingen. As prosector, Merkel was afforded the opportunity to work under Jacob Henle, who was the director of anatomy and the person for which the



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Divine Skin

from ArchDerm - 01 Aug 14

Variation in skin color around the world is a prime example of divergent evolution in humans, with darker skin serving a greater benefit around the equator and lighter skin providing an advantage closer to the poles. Although latitude may roughly correlate with skin pigmentation in our species, the color of the gods we worship is a different discussion entirely!



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Solving the Mystery of Jimmy’s Red Sweat

from ArchDerm - 01 Aug 14

In the 1950s, Harry Hurley and Walter Shelley, distinguished dermatologists at the University of Pennsylvania, devoted considerable attention to the apocrine gland. Their curiosity extended beyond human subjects, and their most fascinating subject was a rotund inhabitant of the Philadelphia Zoo, Jimmy the Hippopotamus.



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JAMA Dermatology

from ArchDerm - 01 Aug 14

Mission Statement: JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician's ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinica



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27 percent of children and adolescents underestimate when guessing their weight, study says

from MNTpaeds - 31 Jul 14

Among children and adolescents, about 27 percent underestimated and nearly 3 percent overestimated their weight status, according to a study from researchers at the University of Massachusetts...



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Mental health and sleep in teenagers: chicken and the egg

from MNTpaeds - 31 Jul 14

TEENAGERS are launched onto a slippery slope of insomnia and poor mental health once they start delaying their bed times according to a new university study from South Australia.



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Children's food intake decisions influenced food preparation by parents

from MNTpaeds - 31 Jul 14

New research suggests that the amount of time parents spend on food preparation at home may affect children's eating behavior away from home and that children whose parents spend more time cooking...



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Guidelines for pediatric preventive care need retooling for computerized format

from MNTpaeds - 31 Jul 14

With the increasing use of electronic medical records and health information exchange, there is a growing demand for a computerized version of the preventive care guidelines pediatricians use across...


 

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