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Overview Photography and Short-term Mole Monitoring in Patients Taking a BRAF Inhibitor

from ArchDerm - 01 Sep 14

Patients taking BRAF inhibitors develop new primary melanomas and nevi. Many of these neoplasms are BRAF wild-type, which may be due to the paradoxical activation of the RAF/MEK/ERK pathway via an alternative driver mutation, similar to the mechanism involved in inducing the development of squamous cell carcinomas in these patients. In addition, some nevi in these individuals involute, and many of these involuting lesions harbor a BRAFV600E (OMIM *164757) mutation.



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Portable Shade Structure Use at a Youth Soccer Camp

from ArchDerm - 01 Sep 14

More than 3 million nonmelanoma skin cancers (NMSCs) are diagnosed annually in the United States. The incidence of malignant melanoma (MM) has increased annually by 2.4%. Open field activities in youth are a major source of sun exposure, which leads to skin cancer later in life. Few studies exist on the use of shade structures in open field sports, particularly soccer. In this pilot study, we assess the rate of use of portable shade structures among soccer-playing youths.



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An Oral Phosphodiesterase Inhibitor (Apremilast) for Inflammatory Rosacea in Adults: A Pilot Study

from ArchDerm - 01 Sep 14

Rosacea is a chronic skin disorder characterized by facial flushing, persistent erythema, telangiectasias, and inflammatory papules and pustules. In addition to the physical manifestations, rosacea may contribute to lower self-esteem, thereby having significant psychosocial implications. Some patients do not respond to conventional treatments for rosacea or are unable to tolerate the adverse effects; therefore, effective new therapies are needed. We sought to investigate the safety and efficacy



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Psoriasis Provoked or Exacerbated by Medications Identifying Culprit Drugs

from ArchDerm - 01 Sep 14

A critical practice gap exists in identifying the causes of psoriasis flares, especially medication-related causes. Some physicians may not consistently examine medications for their contribution to psoriasis flares. However, a careful consideration of the role of medications in psoriasis exacerbation may improve long-term psoriasis control.



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Tumoral Bacillary Angiomatosis in a Child With Human Immunodeficiency Virus

from ArchDerm - 01 Sep 14

Bacillary angiomatosis (BA) is a life-threatening infection caused by gram-negative organisms of the genus Bartonella that can be cured with appropriate therapy. The clinical manifestations of this infection are diverse, and a high index of suspicion and histopathologic analysis are often required to make the diagnosis.



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Development of Trichodysplasia Spinulosa Case Report of a Patient With Gorlin Syndrome Treated With Vismodegib

from ArchDerm - 01 Sep 14

Vismodegib is approved by the US Food and Drug Administration for the treatment of unresectable basal cell carcinoma (BCC) as well as for Gorlin syndrome (basal cell nevus syndrome).



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Mucinous Nevus Report of a Case and Review of the Literature

from ArchDerm - 01 Sep 14

Mucinous nevus is a rare entity characterized by mucin deposition in the papillary dermis. Herein we present a case and review the available literature.



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Poland Syndrome Coexisting With Blaschkolinear Congenital Melanocytic Nevi

from ArchDerm - 01 Sep 14

Poland syndrome is an uncommon congenital anomaly characterized by unilateral chest wall and upper extremity hypoplasia. It is theorized to be due to subclavian artery hypoplasia during embryogenesis. There have been only a few isolated reports of Poland syndrome with congenital dermatoses. Adding to this association list, we report a case of Poland syndrome with multiple congenital melanocytic nevi (CMN). Additionally, the nevi are in a Blaschkolinear arrangement, which is also rare; we know of




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Cutaneous Hemophagocytosis After Alemtuzumab Injection in a Patient With Sézary Syndrome

from ArchDerm - 01 Sep 14

Alemtuzumab, a CD52 monoclonal antibody, is increasingly used for treating advanced cutaneous T-cell lymphomas including Sézary syndrome (SS). While injection site reactions are common, the finding of localized cutaneous hemophagocytosis at the injection site without systemic hemophagocytosis is rare.




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Successful Treatment of Subungual Fibromas of Tuberous Sclerosis With Topical Rapamycin

from ArchDerm - 01 Sep 14

Ungual tumors, a major diagnostic criterion for tuberous sclerosis complex (TSC), are often symptomatic and have posed a therapeutic challenge. We present a case of successful treatment of a subungual fibroma with topical rapamycin.



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Somatic Forward (Nonrevertant) Mosaicism in Recessive Dystrophic Epidermolysis Bullosa

from ArchDerm - 01 Sep 14

Revertant somatic mosaicism is a recognized phenomenon in patients with epidermolysis bullosa (EB) and other inherited diseases. It occurs when spontaneous mutations result in correction of a germline mutation that underlies the genodermatosis, leading to phenotypic reversion and sometimes functional improvement. Revertant mosaicism occurs though several mechanisms, all causing a nonreciprocal transfer of genetic information from the parent cell to the daughter cells. Gene conversions, intrageni



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Dermatology Mobile Applications More Than Just Patient Education

from ArchDerm - 01 Sep 14

To the Editor We read with interest the research letter by Cohen and colleagues that described a mobile application (app) to provide peer-reviewed education to individuals with acne and to identify users’ characteristics. As noted in the research letter and accompanying commentary, mobile apps have significant potential to provide information to large numbers of dermatology patients. However, these apps can and should go far beyond the role of surveying users and providing information and basic



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Error in Byline

from ArchDerm - 01 Sep 14

There was an error in the byline of the Notable Note titled “Tungiasis: ‘The Greatest Curse That Has Ever Afflicted Africa’” in the July issue of JAMA Dermatology (2014;150[7]:708. doi:10.1001/jamadermatol.2014.176). The byline should have read “Fabrizio Vaira, MD, Gianluca Nazzaro, MD, Stephano Veraldi, MD.”



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The Indefensible Defense Enzyme

from ArchDerm - 01 Sep 14

The Journal of Cutaneous DiseasesSeptember 1914THE ABDERHALDEN TECHNIQUE AS APPLIED TO THE DIAGNOSIS OF SYPHILIS.By H. R. Varney, M.D., and P. F. Morse, M.D., Detroit.J Cutan Dis. 1914;32(9):624-629.



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Remembering World War I Joyce Kilmer’s Trees

from ArchDerm - 01 Sep 14

This year marks the 100th anniversary of the start of World War I. There were 116?516 American military personnel killed in this war, including Alfred Joyce Kilmer (1886-1918). He is better known simply as Joyce Kilmer and for his beloved poem called Trees, which begins:



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Leprology and Betrayal in Shakespeare’s Hamlet

from ArchDerm - 01 Sep 14

Before Hansen discovered the lepra bacillus in 1873, there had been dozens of theories on leprosy’s etiology. The most dramatic hypothesis (literally and figuratively) may have been proposed by the ghost of Prince Hamlet’s father in Shakespeare’s play, Hamlet. The ghost recounted the onset of a lethal “lazar-like … vile and loathsome crust” after being poisoned with a “leperous distilment” by the king’s regicidal brother, Claudius (who then usurped the throne—and queen—of Denmark) (Hamlet. Act 1



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The Dark History of White Spots

from ArchDerm - 01 Sep 14

The stigmatization of patients with “white spots” on their skin dates back several millennia. For much of this time, a clear distinction was not made among the various disorders of hypopigmentation. In the Hebrew Bible, Leviticus 13 described a number of such disorders under the broad term Zoraat, denoting white spots. Zoraat was a sign of sin and punishment from God, and the afflicted were considered “unclean” and decreed to live alone. Around 250 bce, Ptolemy II ordered the translation of the



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Carlo Forlanini, the Dermatologist Who Invented the Cure for Pulmonary Tuberculosis

from ArchDerm - 01 Sep 14

Carlo Forlanini was born in 1847 in Milan, Italy, and was the son of Federico Forlanini, the primary doctor from Milan’s Fatebenefratelli Hospital. Carlo was the elder brother of Enrico Forlanini, an inventor and aeronautical pioneer well known for his works on helicopters, aircraft, hydrofoils, and dirigibles. Forlanini joined the faculty of medicine at the University of Pavia. In 1866, he volunteered to serve under Giuseppe Garibaldi, and in 1870 he graduated with a thesis focused on cutaneous



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Saving Their Skins How Animals Protect From the Sun

from ArchDerm - 01 Sep 14

A distinctive evolutionary change experienced by our ancestors as they branched away from their fellow apes was the loss of body hair. While this may have had certain benefits, our species has also suffered drawbacks; for one, without thick fur or hair to scatter sunlight, our skin is more susceptible to burning in the sun. Indeed, sunburns have been observed in other relatively hairless members of the animal kingdom, including whales, dolphins, fish, elephants, and rhinoceroses. But just as hum



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The Ethnic Health and Beauty Section in the US Army and Air Force Post Exchange System

from ArchDerm - 01 Sep 14

The US Department of Defense establishes retail stores (known individually as a post or base exchange [PX or BX]) on military bases to let military personnel buy consumer goods at low cost. Even in combat zones, rudimentary exchanges are often set up within days—or even hours—of the military’s arrival. The shelves of frontline exchanges are well stocked with comfort and convenience items, such as candy, tobacco products, magazines, and personal hygiene items.




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JAMA Dermatology

from ArchDerm - 01 Sep 14

Mission Statement: JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician's ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinica


 

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