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President Kennedy's White House Tan

from ArchDerm - 01 May 13

This year marks the 50th anniversary of the Kennedy assassination. Many of us will never forget that Friday, November 22, 1963, when we heard the tragic news that President John F. Kennedy (1917-1963) had been shot in Dallas, Texas.

Prevalence and Clinical Significance of Anti–Laminin 332 Autoantibodies Detected by a Novel Enzyme-Linked Immunosorbent Assay in Mucous Membrane Pemphigoid Anti–Laminin 332 Autoantibodies Detected by

from ArchDerm - 01 May 13

ImportanceA rare variant of mucous membrane pemphigoid (MMP) is characterized by circulating anti–laminin 332 (Lam332) autoantibodies and seems to be associated with concurrent malignant neoplasms.ObjectiveTo determine the prevalence and clinical significance of anti-Lam332 autoantibody detection from a large series of patients with MMP.DesignMulticenter retrospective study.SettingFour French national centers for autoimmune bullous diseases.ParticipantsOne hundred fifty-four patients with MMP an

Prevalence of Pilomatricoma in Turner Syndrome Findings From a Multicenter Study Prevalence of Pilomatricoma in Turner Syndrome

from ArchDerm - 01 May 13

ImportanceThe absence of data on the prevalence of pilomatricoma among patients with Turner syndrome served as the catalyst for this multicenter investigation.ObjectivesTo ascertain the prevalence of pilomatricoma among patients with Turner syndrome and to determine any association between the development of pilomatricomas and the use of exogenous hormones in patients with Turner syndrome.DesignA retrospective medical record review from January 1, 2000, through January 1, 2010, was performed of

Pruritus Ani, Recurring After Plastic Operation for Its Cure.

from ArchDerm - 01 May 13

THE JOURNAL OF CUTANEOUS DISEASESVOL. XXXIMAY, 1913NO. 5

Pseudoepitheliomatous Hyperplasia: An Unusual Tattoo Reaction

from ArchDerm - 01 May 13

Pseudoepitheliomatous hyperplasia (PEH) is a rare tattoo reaction often arising within areas of red or purple ink. The diagnosis and treatment can be challenging. We report herein the first case to our knowledge of PEH tattoo reaction treated with carbon dioxide laser.

Reliability and Convergent Validity of the Cutaneous Sarcoidosis Activity and Morphology Instrument for Assessing Cutaneous Sarcoidosis Assessment of Cutaneous Sarcoidosis

from ArchDerm - 01 May 13

ImportanceA validated scoring system is essential to assess the effect of therapeutic interventions on a disease. The instrument introduced here captures sarcoidosis disease activity in a reliable, reproducible manner, which will help standardize clinical trial outcomes and allow comparative efficacy studies in the future and may help lead to more robust data regarding the effect of different treatments on cutaneous sarcoidosis.ObjectiveTo assess the reliability and convergent validity of the Cu

Rerecurrence 5 Years After Treatment of Recurrent Cutaneous Basal Cell and Squamous Cell Carcinoma

from ArchDerm - 01 May 13

Cutaneous basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) that have recurred after previous treatment are considered more difficult to cure compared with primary tumors, with overall 5-year re-recurrence rates reported as high as 15.4% for BCC and 5.9% for SCC. Few outcomes data exist from prospective studies, but a randomized controlled study in Europe of facial BCCs found that 5-year recurrence rates after excision or Mohs surgery for 397 primary tumors varied from 2.5% to 4.1

Resistance of Acellular Dermal Matrix Materials to Microbial Penetration Acellular Dermal Matrix Materials

from ArchDerm - 01 May 13

ImportanceAcellular dermal matrices have many current and potential applications, but their long-term safety has not been extensively studied. In particular, limited information exists regarding such materials' resistance to infection.ObjectiveTo assess the resistance to microbial penetration of common acellular dermal matrix materials used in reconstruction after skin cancer excision, treatment of chronic ulcers and burns, breast reconstruction, hernia repairs, and other applications.DesignComp

Saliva Polymerase Chain Reaction Assay for Detection and Follow-up of Herpesvirus Reactivation in Patients With Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) HHV Reactivation in System

from ArchDerm - 01 May 13

ImportanceReactivations of human herpesviruses (HHVs) contribute to the development of drug reaction with eosinophilia and systemic symptoms (DRESS). Diagnosis of HHV reactivation is conventionally based on quantitative real-time polymerase chain reaction (PCR) analysis of blood samples, but these viruses are present in the oropharynx and are shed in saliva.ObjectiveTo evaluate the use of a saliva PCR assay for demonstrating HHV shedding in patients with DRESS.DesignShedding of HHV in saliva was

Solitary Cerebriform Nodule—Diagnosis

from ArchDerm - 01 May 13

Solitary Cerebriform Nodule—Quiz Case

from ArchDerm - 01 May 13

Solitary, Enlarging Painful Violaceous Tumor on the Cheek of a 10-Year-Old—Diagnosis

from ArchDerm - 01 May 13

Solitary, Enlarging Painful Violaceous Tumor on the Cheek of a 10-Year-Old—Quiz Case

from ArchDerm - 01 May 13

Standardizing Training for Psoriasis Measures Effectiveness of an Online Training Video on Psoriasis Area and Severity Index Assessment by Physician and Patient Raters Standardizing Training for Psor

from ArchDerm - 01 May 13

ImportanceBecause the Psoriasis Area and Severity Index (PASI) is the most commonly used and validated disease severity measure for clinical trials, it is imperative to standardize training to ensure reliability in PASI scoring for accurate assessment of disease severity.ObjectiveTo evaluate whether an online PASI training video improves scoring accuracy among patients with psoriasis and physicians on first exposure to PASI.DesignThis equivalency study compared PASI assessment performed by patie

Successful Treatment With Vemurafenib in BRAF V600K–Positive Cerebral Melanoma Metastasis

from ArchDerm - 01 May 13

More than 90% of the BRAF mutations in melanoma are identified at codon 600, and about 80% of these are BRAF V600E mutations. The second most common mutation is the BRAF V600K mutation, representing 14% to 28% of BRAF mutations in melanoma. Vemurafenib treatment for metastatic melanoma has been extensively studied in patients harboring the BRAF V600E mutation. There are rare data concerning the BRAF V600K mutation.

Surgical Excision After Neoadjuvant Therapy With Vismodegib for a Locally Advanced Basal Cell Carcinoma and Resistant Basal Carcinomas in Gorlin Syndrome

from ArchDerm - 01 May 13

Vismodegib is useful to treat locally advanced or metastatic basal cell carcinomas (BCCs), but to our knowledge, its use as a neoadjuvant to shrink BCCs before surgery has not been reported. This case illustrates the role of vismodegib as a neoadjuvant agent. In addition, this case highlights the fact that a patient with Gorlin syndrome can develop resistant BCCs while taking vismodegib, a phenomenon not widely recognized although recently reported.

The American Suntanning Association A “Science-First Organization” With a Biased Scientific Agenda The American Suntanning Association

from ArchDerm - 01 May 13

UV indoor tanning (IT) is a $5 billion-a-year industry in the United States and remains popular despite a growing scientific literature that demonstrates a link between IT and melanoma. The body of evidence linking melanoma to IT has prompted numerous national and international organizations to advocate the avoidance of IT. This list includes the American Medical Association, the American Academy of Dermatology, the US Department of Health and Human Services, and the World Health Organization, a

The Use of Aprepitant in Brachioradial Pruritus

from ArchDerm - 01 May 13

Brachioradial pruritus (BRP) is characterized by intractable itching localized to the dorsolateral aspects of the arms. Aprepitant (Emend; Merck & Co Inc), approved in 2003 for chemotherapy-induced nausea and vomiting, has been used successfully to treat patients with chronic pruritus, but to our knowledge, its use in BRP has not yet been reported.

Tick Removal With Liquid Nitrogen

from ArchDerm - 01 May 13

Lyme disease is a tick-borne zoonosis caused by Borrelia burgdorferi. A causative organism is transmitted via tick bite, Ixodes ricinus in Europe and neighboring parts of North Africa, and Ixodes scapularis and Ixodes pacificus on the west coast of North America. Erythema chronicum migrans is the first, the most common, and the most specific clinical manifestation and a defining criterion for Lyme disease.

Top-Accessed Article: Text-Message Reminders to Improve Sunscreen Use

from ArchDerm - 01 May 13

Armstrong AW, Watson AJ, Makredes M, Frangos JE, Kimball AB, Kvedar JC. Text-message reminders to improve sunscreen use: a randomized, controlled trial using electronic monitoring. Arch Dermatol. 2009;145(11):1230-1236.

Topical Tazarotene for the Treatment of Ectropion in Ichthyosis Topical Tazarotene for Ectropion in Ichthyosis

from ArchDerm - 01 May 13

ImportanceEctropion is a complication of certain subtypes of ichthyosis and is often associated with substantial medical and cosmetic consequences. At present there is no standard of care for the treatment of ectropion in this population. Retinoids cause dyshesion and thinning of stratum corneum, thereby reducing hyperkeratosis that likely underlies ectropion in patients with ichthyosis. As such, retinoids provide a potential effective treatment for ectropion in this group of patients.Observatio

Toward a Better Definition of High-Risk Cutaneous Squamous Cell Carcinoma Comment on “Factors Predictive of Recurrence and Death From Cutaneous Squamous Cell Carcinoma” High-Risk Cutaneous Squamous C

from ArchDerm - 01 May 13

Patient prognosis varies considerably among various types of skin cancer. Approximately 5% of cutaneous squamous cell carcinomas (CSCCs) metastasize, usually to regional nodes. A recent staging system has been developed for CSCC that combines tumor diameter with high-risk features, including primary tumor size greater than 2 cm, Breslow thickness greater than 2 mm, Clark level IV or greater, perineural invasion, poor differentiation, and primary site on the ear or lip, to classify tumors as T1 o

Update on Metastatic Basal Cell Carcinoma: A Summary of Published Cases From 1981 Through 2011

from ArchDerm - 01 May 13

While basal cell carcinoma (BCC) is the most common cancer in the United States, metastasis (mBCC) is extremely rare, with an incidence of 0.0028% to 0.55%. The most recent review of mBCC cases from 1894 through 1980 by von Domarus and Stevens is now 30 years old. We conducted a retrospective systematic evaluation of all published mBCC cases from 1981 through 2011 to update patient demographics and tumor characteristics associated with mBCC and to determine whether adjuvant therapy was associate

Use of Sunlight to Treat Dyshidrotic Eczema

from ArchDerm - 01 May 13

Dyshidrotic eczema is a common complaint. It is very often chronic with recurrences. Although no direct cause of the condition has been identified, immunologic reactions are suggested as a symptom-generating mechanism.

Ustekinumab Therapy for Severe Interstitial Granulomatous Dermatitis With Arthritis

from ArchDerm - 01 May 13

Interstitial granulomatous dermatitis with arthritis (IGDA) is a rare disease that was first described by Ackerman in 1993. Fewer than 70 cases have been reported in the literature, and specific therapies are not available. We report here a case of severe recalcitrant IGDA that was successfully treated with ustekinumab.