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Atropine vs Patching for Treatment of Moderate Amblyopia Follow-up at 15 Years of Age of a Randomized Clinical Trial

from ArchOpht - 01 Jul 14

ImportanceInitial treatment for amblyopia of the fellow eye with patching and atropine sulfate eyedrops improves visual acuity. Long-term data on the durability of treatment benefit are needed.ObjectiveTo report visual acuity at 15 years of age among patients who were younger than 7 years when enrolled in a treatment trial for moderate amblyopia.Design, Setting, and ParticipantsIn a multicenter clinical trial, 419 children with amblyopia (visual acuity, 20/40 to 20/100) were randomly assigned t



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Outer Retinal Corrugations in Age-Related Macular Degeneration

from ArchOpht - 01 Jul 14

ImportanceOptical coherence tomography (OCT) abnormalities of age-related macular degeneration (AMD) have not been fully characterized because of the complex morphology and a lack of correlative histologic studies. Expansion of our ability to interpret increasing attributes brings us closer to the goal of in vivo histologic analysis of the eye by OCT.ObjectiveTo describe a new outer retinal finding of AMD using spectral-domain (SD) OCT and suggest histopathologic correlates.Design, Setting, and



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Beyond Screening for Risk Factors Objective Detection of Strabismus and Amblyopia

from ArchOpht - 01 Jul 14

ImportanceCommercially available automated vision screening devices assess refractive risk factors, not amblyopia or strabismus, underreferring affected children and overreferring healthy children. Nearly half of affected children are not identified until after age 5 years, when treatment is less effective.ObjectivesTo determine the diagnostic accuracy of the Pediatric Vision Scanner (PVS), a binocular retinal birefringence scanner, to objectively identify strabismus and amblyopia, and to compar



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Retinal Morphology of Patients With Achromatopsia During Early Childhood Implications for Gene Therapy

from ArchOpht - 01 Jul 14

ImportanceWhile older children and adults with achromatopsia have been studied, less is known of young children with achromatopsia.ObjectivesTo characterize the macular and foveal architecture of patients with achromatopsia during early childhood with handheld spectral-domain optical coherence tomographic imaging and to make phenotype-genotype correlations.Design, Setting, and ParticipantsComparative case series of 9 patients with achromatopsia and 9 age-matched control participants at a tertiar



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Efficacy and Safety of Antifungal Additives in Optisol-GS Corneal Storage Medium

from ArchOpht - 01 Jul 14

ImportanceOptisol-GS, the most common corneal storage medium in the United States, contains antibacterial but no antifungal supplementation. Most postkeratoplasty endophthalmitis and keratitis cases are now of a fungal origin.ObjectiveTo assess the efficacy and safety of voriconazole and amphotericin B in reducing Candida species contamination of Optisol-GS under normal storage conditions.Design, Setting, and ParticipantsIn vitro laboratory study using 15 pairs of research-grade donor corneas an



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Electronic Monitoring to Assess Adherence With Once-Daily Glaucoma Medications and Risk Factors for Nonadherence The Automated Dosing Reminder Study

from ArchOpht - 01 Jul 14

ImportanceAdherence with topical glaucoma medications is low in some patients. To identify these patients, we need more information on risk factors for nonadherence.ObjectiveTo assess adherence with once-daily glaucoma medication.Design, Setting, and ParticipantsProspective cohort study involving patients who were recruited from a university-based glaucoma clinic and treated with once-daily prostaglandin eyedrops. Baseline characteristics were recorded, and each patient was provided a medication



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Automated Telecommunication-Based Reminders and Adherence With Once-Daily Glaucoma Medication Dosing The Automated Dosing Reminder Study

from ArchOpht - 01 Jul 14

ImportanceTopical glaucoma medications lower intraocular pressure and alter the course of the disease. Because adherence with glaucoma medications is a known problem, interventions are needed to help those patients who do not take their medications as prescribed.ObjectiveTo assess the ability of an automated telecommunication-based intervention to improve adherence with glaucoma medications.Design, Setting, and ParticipantsWe performed a prospective cohort study of medication adherence, followed



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Ocular Adnexal Follicular Lymphoma A Multicenter International Study

from ArchOpht - 01 Jul 14

ImportanceThe clinical features of the follicular subtype of ocular adnexal lymphoma (OAL) have not been previously evaluated in a large cohort.ObjectiveTo characterize the clinical features of follicular OAL.Design, Setting, and ParticipantsWe performed a retrospective multicenter study that involved 6 eye cancer centers from January 1, 1980, through December 31, 2010. A total of 105 patients with follicular OAL were identified, of which 7 patients were excluded because of missing clinical data



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Evaluation of Retinal Nerve Fiber Layer Thickness in Eyes With Hypertensive Uveitis

from ArchOpht - 01 Jul 14

ImportanceUveitic glaucoma is among the most common causes of irreversible visual loss in uveitis. However, glaucoma detection can be obscured by inflammatory changes.ObjectiveTo determine whether retinal nerve fiber layer (RNFL) measurement can be used to detect glaucoma in uveitic eyes with elevated intraocular pressure (IOP).Design, Setting, and ParticipantsComparative case series of RNFL measurement using optical coherence tomography performed from May 1, 2010, through October 31, 2012, at a



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Four-Year Placebo-Controlled Trial of Docosahexaenoic Acid in X-Linked Retinitis Pigmentosa (DHAX Trial) A Randomized Clinical Trial

from ArchOpht - 01 Jul 14

ImportanceX-linked retinitis pigmentosa is a severe inherited retinal degenerative disease with a frequency of 1 in 100?000 persons. Because no cure is available for this orphan disease and treatment options are limited, slowing of disease progression would be a meaningful outcome.ObjectiveTo determine whether high-dose docosahexaenoic acid (DHA), an ?-3 polyunsaturated fatty acid, slows progression of X-linked retinitis pigmentosa measured by cone electroretinography (ERG).Design, Setting, and



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Ophthalmologic Examinations in Areas of Miyagi Prefecture Affected by the Great East Japan Earthquake

from ArchOpht - 01 Jul 14

ImportanceOne month after the Great East Japan Earthquake on March 11, 2011, our clinic was granted free use of the Mission Vision Van, a customized bus airlifted to Japan. This mobile eye clinic made it possible for us to provide ophthalmologic examinations anywhere in the disaster zone in Miyagi Prefecture. ObservationsThis study included 731 patients who received treatment in the eye care van in Miyagi Prefecture between April 15 and May 29, 2011. We examined and cared for patients during 25



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Paradoxical Changes of Retinal Nerve Fiber Layer Thickness in Uveitic Glaucoma

from ArchOpht - 01 Jul 14

ImportanceMeasurement of retinal nerve fiber layer (RNFL) thickness using optical coherence tomography can aid in the diagnosis and management of glaucoma. We observed a previously unreported phenomenon in eyes with uveitis-associated glaucoma in which paradoxical changes in RNFL thickness were noted.ObservationsFour eyes of 3 patients with uveitis-associated glaucoma had a relatively normal RNFL measurement on presentation during periods of active uveitis and raised intraocular pressure. Subseq



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Acute Retinal Necrosis Associated With Epstein-Barr Virus Immunohistopathologic Confirmation

from ArchOpht - 01 Jul 14

ImportanceAcute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history and histopathologic confirmation that EBV can cause ARN.ObservationsClinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology.Conclusions and Relevan



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Congenital Cataract Surgery During the Early Enlightenment Period and the Stepkins Oculists

from ArchOpht - 01 Jul 14

From antiquity through the Renaissance, congenital blindness was generally regarded as incurable, as noted in both medical and lay publications. The earliest reference to congenital cataract surgery that we identified, reported in 1663, referred to an 18-year-old female treated by English oculist John Stepkins (d. 1652). An examination of the literature related to the Stepkins family reveals the presence of male and female oculists during that period, including his daughter, Lady Theodosia Ivy.





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Evaluation of Results 1 Year Following Short-term Use of Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy

from ArchOpht - 01 Jul 14

Vitreous hemorrhage from proliferative diabetic retinopathy can cause vision loss and preclude panretinal photocoagulation (PRP). The Diabetic Retinopathy Clinical Research Network (DRCR.net) investigated whether intravitreal ranibizumab compared with intravitreal saline had a beneficial effect on the vitrectomy rates of eyes with vitreous hemorrhage from proliferative diabetic retinopathy precluding complete PRP. Eyes were randomly assigned to 0.5 mg of ranibizumab (n?=?125) or saline (n?=?136)



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Sealing Effect of External Diathermy on Leaking Sclerotomies After Small-Gauge Vitrectomy A Clinicopathological Report

from ArchOpht - 01 Jul 14

Small-gauge vitrectomy has surged in popularity in recent years and has become a widespread alternative to traditional techniques. Eighty-five percent of retinal surgeons now routinely use 25- or 23-gauge systems for uncomplicated macular surgery compared with 22% in 2005.



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Epstein-Barr Virus–Positive Polymorphous Lymphoplasmacytic Infiltrate of the Lacrimal Glands in a Patient With Acute Lymphoblastic Leukemia

from ArchOpht - 01 Jul 14

An atypical inflammatory infiltrate of the orbital tissues in the setting of a patient with a known history of treated leukemia presents the clinician with the daunting task of having to establish whether a relapse of the leukemia has occurred, which would necessitate reintroduction of toxic chemotherapeutic agents. Herein, we report such a case.



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Novel Telemedicine Device for Diagnosis of Corneal Abrasions and Ulcers in Resource-Poor Settings

from ArchOpht - 01 Jul 14

Corneal ulcers are a significant cause of corneal blindness worldwide. Normally, traumatic corneal damage and secondary infections are diagnosed by an ophthalmologist via slitlamp examination. However, limited health care resources in developing regions may delay diagnosis and treatment, increasing the risk of vision loss. Mobile phones are widely available even in resource-limited settings and therefore could potentially be used to aid in diagnosis of corneal pathology. Herein, we describe and



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Subretinal Thelazia -Induced Diffuse Unilateral Subacute Neuroretinitis

from ArchOpht - 01 Jul 14

Diffuse unilateral subacute neuroretinitis (DUSN) is a parasitic eye infection with characteristic abnormalities of the outer retina and retinal pigment epithelium and is caused by nematode infection, which can be located in the subretinal space. It is a primarily unilateral ocular disorder clinically characterized by a decrease in vision associated with vitritis, papillitis, and recurrent development of white linear lesions in the retina. The gold standard of the diagnosis of DUSN is the visual



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Alternating Superior and Inferior Oblique Myokymia

from ArchOpht - 01 Jul 14

The well-described phenomenon of superior oblique myokymia and the more recently described unique motility disorder inferior oblique myokymia are both defined as monocular, high-frequency, low-amplitude contractions of the superior or inferior oblique muscles that produce torsional oscillopsia. Symptoms vary in duration from seconds to hours and have varying frequency, while remissions and exacerbations often last months or years. Although of unknown etiology, current considerations include vasc



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Reversible Nyctalopia and Retinopathy in a Patient With Metastatic Cancer Treated With Anti–Heat Shock Protein 90 Therapy

from ArchOpht - 01 Jul 14

Cancer-associated retinopathy is an autoimmune disease in which autoantibodies trigger retinal tissue destruction. Patients with cancer-associated retinopathy may develop visual acuity or visual field loss, photopsias, photophobia, and/or nyctalopia. Drug-induced toxic effects can also cause photoreceptor damage and corresponding visual symptoms. We describe a patient with nyctalopia during treatment of non–small cell lung cancer with AUY922, a heat shock protein 90 (HSP90) inhibitor.



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Concurrent Primary Vitreoretinal and Spinal Cord Lymphoma A Unique Entity

from ArchOpht - 01 Jul 14

Primary central nervous system lymphoma is a rare non-Hodgkin B-cell lymphoma limited to the central nervous system and distinct from systemic lymphoma with secondary central nervous system involvement. More than 15% of patients with primary central nervous system lymphoma develop vitreoretinal lymphoma involving the retina and/or vitreous, typically misdiagnosed for autoimmune, infectious, demyelinating, vascular, neoplastic, and paraneoplastic conditions. Primary spinal cord lymphoma is a subt


 

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