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Aphakic Pupillary Block

from ArchOpht - 12 Feb 15

A man in his early 60s presented with eye pain after blunt trauma. A, Examination revealed aphakia with vitreous in the anterior chamber (arrowheads). B, Anterior segment optical coherence tomography demonstrated pupillary block due to vitreous prolapse, which resolved after peripheral iridotomy.



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Detachment of Donor Graft After Descemet Stripping Automated Endothelial Keratoplasty

from ArchOpht - 12 Feb 15

The donor disc was found detached 1 week following Descemet stripping automated endothelial keratoplasty. A, Optical coherence tomography revealed an inverted graft with the endothelium side up. B, After surgical reorientation of the detached graft, a favorable surgical outcome was achieved.



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Embolic Anterior Ischemic Optic Neuropathy Associated With a Hollenhorst Plaque

from ArchOpht - 12 Feb 15

Embolization causing a branch retinal artery occlusion and nonarteritic anterior ischemic optic neuropathy. Fundus photography shows a superior nasal disc edema and an inferior temporal Hollenhorst plaque (arrowhead) with an adjacent area of retinal ischemia in the left eye.



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Natural History of Valsalva-Induced Subhyaloid Hemorrhage

from ArchOpht - 12 Feb 15

A, A 29-year-old man presented with subhyaloid hemorrhage in his left eye after lifting weights. B, After 1 month of observation, the hemorrhage dehemoglobinized. C, At 3 months, his vision improved with resolution of the hemorrhage. CF indicates counting fingers. The fundus photographs and spectral-domain optical coherence tomographic images were provided by Dennis C. Donovan, COA.



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Tarsal IgG4-Related Disease

from ArchOpht - 12 Feb 15

A 59-year-old woman with a history of asthma exhibited a bilateral tarsal lesion (A) that histologically showed lymphoplasmacytic infiltrations (B) (hematoxylin-eosin, original magnification ×40) with a high ratio (0.5) of IgG4 (C) (immunoperoxidase, original magnification ×200) to IgG (D) (immunoperoxidase, original magnification ×200). The lesion responded to a local injection of triamcinolone acetonide.



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Case of Rapidly Progressing Buried Optic Nerve Head Drusen

from ArchOpht - 12 Feb 15

A, Normal-looking fundus (F/9). B, Elevated optic disc with blurred margins, 3 years later. The hyper reflective subretinal mass (arrowhead) on spectral-domain optical coherence tomography (C) and B-scan (D) is consistent with buried optic nerve head drusen. This implies a relatively rapid progression. The small optic disc, a predisposition of optic nerve head drusen, is not present.



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Ophthalmomyiasis: A Lit Path

from ArchOpht - 12 Feb 15

A 15-year-old adolescent boy presented with blurry vision in the right eye, a hyphema, and 20/25 visual acuity. A dilated examination revealed depigmented criss-crossing tracks and a fly larva inferotemporally (inset). Fluorescein angiography demonstrated the path taken by the larva.



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Unilateral Ocular Pseudopemphigoid in a Patient With Glaucoma

from ArchOpht - 12 Feb 15

A patient with glaucoma continued use of topical medications in the right eye (A-C) and underwent trabeculectomy in the left eye (D-F). The right eye developed chronic conjunctival inflammation, fibrosis, and symblepharon (arrowheads in A and C). A right trabeculectomy and suspension of topical treatment resolved the inflammation and symptoms.




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Severity of Age-Related Macular Degeneration in 1 Eye and the Incidence and Progression of Age-Related Macular Degeneration in the Fellow Eye The Beaver Dam Eye Study

from ArchOpht - 01 Feb 15

ImportancePrevious studies regarding the severity of age-related macular degeneration (AMD) in 1 eye and its prognostic implications for the fellow eye have focused on the incidence of neovascular AMD in the fellow eye of participants with neovascular AMD in the other eye. It is unclear to what extent the severity of AMD in 1 eye affects the incidence, progression, and regression of AMD in its fellow eye across the entire range of AMD severity.ObjectiveTo investigate the effect of the severity o



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New Mutations in the RAB28 Gene in 2 Spanish Families With Cone-Rod Dystrophy

from ArchOpht - 01 Feb 15

ImportanceThe families evaluated in this study represent the second report of cone-rod dystrophy (CRD) cases caused by mutations in RAB28, a recently discovered gene associated with CRD.ObjectiveTo determine the disease-causing gene in 2 families of Spanish descent presenting with CRD who do not have ABCA4 mutations.Design, Setting, and ParticipantsMolecular genetics and observational case studies of 2 families, each with 1 affected proband with CRD and 3 or 5 unaffected family members. The affe



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The Value of Measuring Urinary ß2-Microglobulin and Serum Creatinine for Detecting Tubulointerstitial Nephritis and Uveitis Syndrome in Young Patients With Uveitis

from ArchOpht - 01 Feb 15

ImportanceTubulointerstitial nephritis and uveitis (TINU) syndrome is characterized by tubulointerstitial and ocular inflammation. Thus far, the value of noninvasive diagnostic tests is not known.ObjectiveTo determine whether urinary ß2-microglobulin (ß2M), urinary protein, and serum creatinine have predictive value for detecting TINU syndrome in young patients with uveitis.Design, Setting, and ParticipantsThis prospective cohort study was conducted July 2010 through February 2013 at a tertiary



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Filtering Blebs Using 3-Dimensional Anterior-Segment Optical Coherence Tomography A Prospective Investigation

from ArchOpht - 01 Feb 15

ImportancePosttrabeculectomy changes in bleb parameters measured using 3-dimensional (3-D) anterior-segment optical coherence tomography (OCT) remain uncharacterized and might be related to postsurgical intraocular-pressure (IOP) control.ObjectiveTo evaluate time-dependent posttrabeculectomy changes in filtering bleb parameters using 3-D anterior-segment OCT.Design, Setting, and ParticipantsThis prospective observational study was conducted at Kumamoto University Hospital, Kumamoto, Japan. Patie



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Clinical Aspects of Usher Syndrome and the USH2A Gene in a Cohort of 433 Patients

from ArchOpht - 01 Feb 15

ImportanceA new statistical approach is needed to describe the clinical differences between type I and type II Usher syndrome and between the 2 most frequent mutations in the USH2A gene.ObjectivesTo describe the primary phenotypic characteristics and differences between type I and type II Usher syndrome and to establish a phenotype-genotype correlation for the 2 most frequent mutations in the USH2A gene.Design, Setting, and ParticipantsCross-sectional study at a genetics department, in which cli



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Ocular Adnexal Diffuse Large B-cell Lymphoma A Multicenter International Study

from ArchOpht - 01 Feb 15

ImportanceThe clinical features of diffuse large B-cell lymphoma (DLBCL) subtype of ocular adnexal lymphoma have not previously been evaluated in a large cohort to our knowledge.ObjectiveTo investigate the clinical features of ocular adnexal DLBCL (OA-DLBCL).Design, Setting, and ParticipantsThis retrospective international cooperative study involved 6 eye cancer centers. During 30 years, 106 patients with OA-DLBCL were identified, and 6 were excluded from the study. The median follow-up period w



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Diabetes Eye Screening in Urban Settings Serving Minority Populations Detection of Diabetic Retinopathy and Other Ocular Findings Using Telemedicine

from ArchOpht - 01 Feb 15

ImportanceThe use of a nonmydriatic camera for retinal imaging combined with the remote evaluation of images at a telemedicine reading center has been advanced as a strategy for diabetic retinopathy (DR) screening, particularly among patients with diabetes mellitus from ethnic/racial minority populations with low utilization of eye care.ObjectiveTo examine the rate and types of DR identified through a telemedicine screening program using a nonmydriatic camera, as well as the rate of other ocular



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Prevention of Nocturnal Elevation of Intraocular Pressure by Gene Transfer of Dominant-Negative RhoA in Rats

from ArchOpht - 01 Feb 15

ImportanceWe developed a gene transfer tool for the control of nocturnal elevated intraocular pressure (IOP).ObjectiveTo demonstrate that inhibiting the trabecular meshwork RhoA pathway by delivering a mutated, dominant-negative RhoA gene (dnRhoA) carried inside a long-expressing recombinant virus would reduce nocturnal elevated IOP in a living animal.Design and SettingWe generated an optimized recombinant viral molecule by inserting a mutated RhoA complementary DNA with a translation enhancer-p



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Treatment Strategies in Primary Vitreoretinal Lymphoma A 17-Center European Collaborative Study

from ArchOpht - 01 Feb 15

ImportanceThe best treatment option for primary vitreoretinal lymphoma (PVRL) without signs of central nervous system lymphoma (CNSL) involvement determined on magnetic resonance imaging or in cerebrospinal fluid is unknown.ObjectiveTo evaluate the outcomes of treatment regimens used for PVRL in the prevention of subsequent CNSL.Design, Setting, and ParticipantsA retrospective cohort study was conducted at 17 referral ophthalmologic centers in Europe. We reviewed clinical, laboratory, and imagi



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Telemedicine Screening for Cytomegalovirus Retinitis at the Point of Care for Human Immunodeficiency Virus Infection

from ArchOpht - 01 Feb 15

ImportanceCytomegalovirus (CMV) retinitis is a leading cause of blindness in many developing countries, likely the result of inadequate screening. Telemedicine screening for CMV retinitis instituted at the point of care for human immunodeficiency virus (HIV) infection may allow for earlier detection.ObjectivesTo determine the diagnostic accuracy of retinal photography in detecting CMV retinitis at the point of HIV care and to characterize the clinical manifestations of CMV retinitis detected thr



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Efficacy of Selective Laser Trabeculoplasty in Primary Angle-Closure Glaucoma A Randomized Clinical Trial

from ArchOpht - 01 Feb 15

ImportanceSelective laser trabeculoplasty (SLT) should be explored as a therapeutic option in eyes with angle closure.ObjectiveTo assess the intraocular pressure (IOP)–lowering efficacy of SLT in eyes with primary angle closure (PAC) and PAC glaucoma (PACG).Design, Setting, and ParticipantsRandomized clinical trial at tertiary eye care institutions of 100 patients diagnosed as having PAC or PAC glaucoma in which the angles had opened at least 180° (visible posterior trabecular meshwork on gonios



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Nibbling Away at the Diagnosis of Idiopathic Uveitis

from ArchOpht - 01 Feb 15

Mrs N fidgeted behind me as I focused the slitlamp beam on her daughter’s eye. “Laura has anterior uveitis,” I pronounced.



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Robotically Assisted Amniotic Membrane Transplant Surgery

from ArchOpht - 01 Feb 15

Amniotic membrane transplant (AMT) is a surgical technique for ocular surface reconstruction that should be considered for acute chemical or thermal burns, painful bullous keratopathy, shield ulcers, severe bacterial keratitis, necrotizing herpetic keratitis, corneal thinning, refractory neurotrophic keratitis, and other persistent epithelial defects (PED). The literature describes several techniques to place and fix the amniotic membrane (AM). The amniotic membrane may be used as a graft (inlay





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Quantitative Autofluorescence as a Clinical Tool for Expedited Differential Diagnosis of Retinal Degeneration

from ArchOpht - 01 Feb 15

Homozygous and compound heterozygous mutations in ABCA4 are associated with multiple phenotypes, including bull’s-eye maculopathy (BEM). The BEM fundus patterning can also be conferred by other genes such as the retinitis pigmentosa guanosine triphosphatase regulator gene (RPGR), a gene that encodes a protein involved in trafficking to the outer segment. The carrier frequency of disease-causing mutations in ABCA4 is 1 in 20. Even after complete sequencing of the ABCA4 exons and adjacent intronic


 

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