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The First International Optogenetic Therapies for Vision Symposium Translational Medicine in Progress

from ArchOpht - 01 Sep 14

Optogenetics is a technology that uses gene therapy to induce the expression of light-activated ion channels in cells, which renders the cells light-sensitive. When these cells are illuminated with light of the proper wavelength, membrane depolarization (or hyperpolarization) is induced by the light-sensitive ion channels, and if the cells are neurons, synaptic transmission can be initiated (or inhibited). Optogenetics has the potential for minimally invasive neuronal stimulation with high spati



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Effect of a Teleretinal Screening Program on Eye Care Use and Resources

from ArchOpht - 01 Sep 14

ImportanceTelemedicine is a useful clinical method to extend health care to patients with limited access. Minimal information exists on the subsequent effect of telemedicine activities on eye care resources.ObjectiveTo evaluate the effect of a community-based diabetic teleretinal screening program on eye care use and resources.Design, Setting, and ParticipantsThe current study was a retrospective medical record review of patients who underwent diabetic teleretinal screening in the community-base



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Telemedicine Diagnosis of Cytomegalovirus Retinitis by Nonophthalmologists

from ArchOpht - 01 Sep 14

ImportanceCytomegalovirus (CMV) retinitis continues to be a leading cause of blindness in many developing countries. Telemedicine holds the potential to increase the number of people screened for CMV retinitis, but it is unclear whether nonophthalmologists could be responsible for interpreting fundus photographs captured in a telemedicine program.ObjectiveTo determine the accuracy of nonophthalmologist photographic graders in diagnosing CMV retinitis from digital fundus photographs.Design, Setti



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Postoperative Glaucoma Following Infantile Cataract Surgery An Individual Patient Data Meta-analysis

from ArchOpht - 01 Sep 14

ImportanceInfantile cataract surgery bears a significant risk for postoperative glaucoma, and no consensus exists on factors that may reduce this risk.ObjectiveTo assess the effect of primary intraocular lens implantation and timing of surgery on the incidence of postoperative glaucoma.Data SourcesWe searched multiple databases to July 14, 2013, to identify studies with eligible patients, including PubMed, MEDLINE, EMBASE, ISI Web of Science, Scopus, Central, Google Scholar, Intute, and Tripdata



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Optic Disc Characteristics in Patients With Glaucoma and Combined Superior and Inferior Retinal Nerve Fiber Layer Defects

from ArchOpht - 01 Sep 14

ImportanceEyes with initial bihemifield defects show faster progression compared with eyes with initial single-hemifield involvement, suggesting greater optic nerve susceptibility to glaucomatous damage. We hypothesized that certain disc phenotypes may exist in patients with glaucoma who have bihemispheric structural damage at the initial stage of the disease.ObjectiveTo identify the optic disc characteristics related to bihemispheric retinal nerve fiber layer (RNFL) defects in early-stage glauc



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Identification of CNGA3 Mutations in 46 Families Common Cause of Achromatopsia and Cone-Rod Dystrophies in Chinese Patients

from ArchOpht - 01 Sep 14

ImportanceMutations in CNGA3 are the most common cause of achromatopsia and cone-rod dystrophies.ObjectiveTo identify CNGA3 mutations in patients with cone dystrophies or Leber congenital amaurosis.Design, Setting, and ParticipantsClinical data and genomic DNA in 267 Chinese probands from 138 families with cone dystrophies and 129 families with Leber congenital amaurosis collected at the Zhongshan Ophthalmic Center, Guangzhou, China.Main Outcomes and MeasuresVariants in CNGA3 and associated phen



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Concentric Macular Rings Sign in Patients With Foveal Hypoplasia

from ArchOpht - 01 Sep 14

ImportanceWe describe a sign that can be used as a rapid and noninvasive adjunct to aid in the diagnosis of foveal hypoplasia.ObjectiveTo describe a concentric macular rings sign found on infrared reflectance (IRR) images in patients with foveal hypoplasia.Design, Setting, and PatientsWe studied 13 patients with foveal hypoplasia (7 with ocular albinism [OA], 5 with oculocutaneous albinism [OCA], and 1 with aniridia) at a tertiary ophthalmology center with access to electrodiagnostic services fr



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Acute Zonal Occult Outer Retinopathy A Classification Based on Multimodal Imaging

from ArchOpht - 01 Sep 14

ImportanceWe describe the multimodal imaging in a group of patients showing a distinct clinical entity that best represents acute zonal occult outer retinopathy (AZOOR).ObjectiveTo propose a classification of AZOOR based on clinical fundus and multimodal imaging.Design, Setting and ParticipantsA retrospective review of patients diagnosed as having AZOOR at 2 centers. After reviewing more than 400 cases diagnosed or referred to us as AZOOR or AZOOR complex, we assembled 30 cases that fit our curr



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Fluorescence Adaptive Optics Scanning Laser Ophthalmoscope for Detection of Reduced Cones and Hypoautofluorescent Spots in Fundus Albipunctatus

from ArchOpht - 01 Sep 14

ImportanceFundus albipunctatus (FA) is a form of congenital stationary night blindness characterized by yellow-white spots, which were classically described as subretinal. Although night blindness and delayed dark adaptation are hallmarks of this condition, recent studies have described a macular phenotype, particularly among older patients. Using a fluorescence adaptive optics scanning laser ophthalmoscope (FAOSLO), this study provides in vivo morphologic data at the cellular level in FA.Object



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Effect of Disease Stage on Progression of Hydroxychloroquine Retinopathy

from ArchOpht - 01 Sep 14

ImportanceHydroxychloroquine sulfate retinopathy can progress after the drug is stopped. It is not clear how this relates to the stage of retinopathy or whether early screening with modern imaging technology can prevent progression and visual loss.ObjectiveTo determine the relationship between progression of retinopathy and the severity of disease using objective data from optical coherence tomography and assess the value of early screening for the toxic effects of hydroxychloroquine.Design, Set



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Reproducibility of Spectral-Domain Optical Coherence Tomography Retinal Thickness Measurements and Conversion to Equivalent Time-Domain Metrics in Diabetic Macular Edema

from ArchOpht - 01 Sep 14

ImportanceUnderstanding measurement variability and relationships between measurements obtained on different optical coherence tomography (OCT) machines is critical for clinical trials and clinical settings.ObjectiveTo evaluate the reproducibility of retinal thickness measurements from OCT images obtained by time-domain (TD) (Stratus; Carl Zeiss Meditec) and spectral-domain (SD) (Cirrus; Carl Zeiss Meditec, and Spectralis; Heidelberg Engineering) instruments and formulate equations to convert re



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Prolonged Curvularia Endophthalmitis Due to Organism Sequestration

from ArchOpht - 01 Sep 14

ImportanceEndophthalmitis caused by Curvularia is a rare condition seen after cataract surgery and trauma. The clinical course has not been described previously.ObjectiveTo examine the clinical course of 6 postoperative and trauma-related cases of Curvularia endophthalmitis.Design, Setting, and ParticipantsRetrospective case series. We reviewed the archives of the microbiology laboratory of Bascom Palmer Eye Institute, a tertiary referral hospital, from January 1, 1980, through September 30, 201



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Management of Functional Epiphora in Patients With an Anatomically Patent Dacryocystorhinostomy

from ArchOpht - 01 Sep 14

ImportanceApproximately 5% to 10% of patients continue to experience persistent epiphora following an anatomically successful dacryocystorhinostomy (DCR) for nasolacrimal duct obstruction or stenosis.ObjectiveTo investigate the management and success rate of so-called “functional failure” of DCR for nasolacrimal duct obstruction by experienced lacrimal surgeons.Design, Setting, and ParticipantsMulticenter retrospective case series including 5 Australian and New Zealand centers. Participants incl



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Histopathological and Immunohistochemical Analysis of Melt-Associated Retroprosthetic Membranes in the Boston Type 1 Keratoprosthesis

from ArchOpht - 01 Sep 14

ImportanceRetroprosthetic membrane (RPM) formation is the most common complication associated with the Boston type 1 keratoprosthesis and has been associated with corneal melt.ObjectiveTo identify the histological and immunohistochemical characteristics of RPMs associated with corneal melt.Design, Setting, and ParticipantsObservational histopathological case series at a tertiary eye care referral center among patients who underwent Boston type 1 keratoprosthesis explantation because of donor cor



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Effect of Doxycycline vs Placebo on Retinal Function and Diabetic Retinopathy Progression in Mild to Moderate Nonproliferative Diabetic Retinopathy A Randomized Proof-of-Concept Clinical Trial

from ArchOpht - 01 Sep 14

ImportanceMicroglia have been associated with inflammatory changes underlying diabetic retinopathy. ObjectiveTo investigate whether low-dose oral doxycycline monohydrate, a drug capable of inhibiting microglial activation, can improve or slow the deterioration of retinal function and whether it can induce regression or slow progression of diabetic retinopathy in patients with mild to moderate nonproliferative diabetic retinopathy (NPDR).Design, Setting, and ParticipantsRandomized, double-masked,





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Enhanced Vitreous Imaging Technique With Spectral-Domain Optical Coherence Tomography for Evaluation of Posterior Vitreous Detachment

from ArchOpht - 01 Sep 14

Vitreous degeneration, gradual separation of the posterior vitreous cortex (PVC), and eventual development of posterior vitreous detachment (PVD) are important in vitreoretinal interface diseases. However, determination of the stages of PVD with biomicroscopy or ultrasonography is not sufficiently sensitive and specific. Since the advent of spectral-domain (SD) optical coherence tomography (OCT), PVD detection has improved and new concepts regarding the evolution of PVD have emerged. However, SD



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Development of Bilateral Acquired Toxoplasmic Retinochoroiditis During Erlotinib Therapy

from ArchOpht - 01 Sep 14

Toxoplasma gondii retinochoroiditis is the most common cause of posterior uveitis in North America. Immunocompromised patients are particularly susceptible, and bilateral acquired toxoplasmic retinochoroiditis is thought to be rare without immunosuppression. We describe a woman who developed bilateral acquired toxoplasmic retinochoroiditis while undergoing treatment with erlotinib hydrochloride, an epidermal growth factor receptor tyrosine kinase inhibitor, in the absence of other immunomodulato



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Outer Segment Length in Different Best Disease Genotypes

from ArchOpht - 01 Sep 14

To the Editor We were interested to read the recent article by David B. Kay et al in which adaptive optics scanning laser ophthalmoscopy and spectral-domain optical coherence tomography (SD-OCT) were used to study the retinas of 4 patients with the Arg218Cys mutation in BEST1. The application of adaptive optics scanning laser ophthalmoscopy to Best disease and other inherited macular diseases is contributing exciting new information on the photoreceptor mosaic that was previously unavailable, an



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Outer Segment Length in Different Best Disease Genotypes—Reply

from ArchOpht - 01 Sep 14

In Reply We agree that genotype-phenotype differences in patients with BEST1 mutations are poorly understood and may underlie the apparent differences between the 2 studies. Furthermore, light adaptation at the time of SD-OCT imaging acquisition can affect the appearance of the outer retinal bands, as shown recently by Abràmoff et al and Godara et al. As we did not control for light adaptation at the time of SD-OCT imaging acquisition in patients with Best vitelliform macular dystrophy, this mig



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Incorrect Spelling of Author’s Last Name

from ArchOpht - 01 Sep 14

In the article titled “Expansion of Ocular Phenotypic Features Associated With Mutations in ADAMTS18,” published online May 29, 2014, and in the August print issue of JAMA Ophthalmology (doi:10.1001/jamaophthalmol.2014.940), the fourth author’s last name was spelled incorrectly in the byline and the Author Contributions section. The fourth author’s full name should have appeared as Panagiotis I. Sergouniotis, PhD. This article was corrected online and in print.



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Nevus in a Pterygium

from ArchOpht - 01 Sep 14

A 23-year-old man presented with a 2-year history of a slow growing lesion in the left eye. The lesion consisted of a vascularized, balloon-like mass straddling the limbus nasally (A). Histopathologic examination demonstrates (B) a conjunctival epithelium with solar elastosis, consistent with a pterygium (left side), and proliferation of melanocytic cells in the stroma and epithelial-stromal interface, consistent with a compound nevus (right side). It is important to note that, except for a smal



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Acquired Trichomegaly Trichomegaly Secondary to Erlotinib

from ArchOpht - 01 Sep 14

Front (A) and lateral (B) external photographs of a woman in her early 60s who had undergone treatment with erlotinib for more than 2 and a half years. She developed bilateral trichomegaly, which required constant trimming.


 

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