from Am J Surg - 06 Oct 14
Evolution of Insulin: From Human to Analog.
Am J Med. 2014 Oct;127(10S):S25-S38
Authors: Tibaldi JM
The development of insulin analogs has made improved treatment of type 2 diabetes possible. In this article, structural alterations, pharmacokinetics and pharmacodynamics, clinical end points, and safety issues are reviewed for the currently available basal insulins, rapid-acting insulins, and premixes. The flatter activity profiles of i